Supplements help patients with advanced Alzheimer’s disease
Recent human studies have demonstrated the benefits of a vitamin with nutraceutical formulation supplying Folate, vitamin B6, alpha-tocopherol vitamin E, SAMe, NAC and ALCAR for patients with Alzheimer's disease at mild to moderate stages. The researchers have now tested this formulation for effect in a small cohort of 12 institutionalized patients diagnosed with moderate-stage to later-stage Alzheimer's disease.
This formulation holds promise for delaying the decline in cognition, mood, and daily function that accompanies the progression of Alzheimer's disease, and may be particularly useful as a supplement for pharmacological approaches during later stages of this disorder. A larger trial is warranted. The study is published online ahead of print in the December 3rd, 2008 edition of the American Journal of Alzheimer’s Disease and Other Dementias.
Participants were randomly separated into either a nutritional treatment group or a placebo group. Participants receiving the formulation demonstrated a clinically significant delay in decline in the Dementia Rating Scale and clock-drawing test as compared to those receiving placebo. Institutional caregivers reported approximately 30% improvement in the Neuropyschiatric Inventory and maintaining better performance in daily living for more than 9 months.