Role of Policosanol in the Prevention and Treatment of Cardiovascular Disease
Policosanols are a mixture of plant cosanols (waxy alcohols)
derived from sugar cane wax. When administered at 5mg to 20mg a
day, Policosanols decrease the creation of plaques in the arteries.
They accomplish this by reducing improper clotting, reducing blood
vessel wall inflammation and damage, and by decreasing the creation
of scar-tissue-plaques in the artery walls (what eventually is bad
enough to earn the name atherosclerosis or cardiovascular disease).
Additionally sugar cane waxed Policosanols have been shown to
decrease total cholesterol by 13% to 23%, lower dangerous
LDL-cholesterol by 19% to 31%, while increasing the protective
HDL by 8% to 29%. Policosanols reduce the creation of cholesterol
while also increasing its rate of excretion. When compared with
statins, Policosanols exhibit comparable cholesterol lowering
effects at much smaller doses. The study is published in the
November 2003 issue of the journal Nutrition Reviews.
Resveratrol Protects Breast Tissue
The drugs Evista (raloxifene) and tamoxifen are used to protect
women from developing breast cancer. They are called anti-estrogens.
The anti-estrogens protect women by defending the genetic material
in breast cells (DNA) from oxidative-free radical damage caused
by estrogens especially 17-betaestradiol. In a new study the red
grape skin antioxidant Resveratrol has this same activity in breast
tissue. The anti-estrogens and Resveratrol stimulate levels of an
enzyme known as Quinone Reductase. This enzyme is a potent detoxifying
enzyme that removes dangerous chemicals from the body. In the breast
Quinone Reductase shields breast tissue and DNA from free radical
damage, possibly decreasing the risk of breast cancer. The study
is published in the September 30th, 2004 issue of the Biochemical
Resveratrol Improves the Activity of Chemotherapy for Liver Cancer
Liver cancer was induced in mice. Resveratrol was supplemented at
a dosage of 10mg/kg or 15mg/.kg versus inactive placebo for 10
days. The Resveratrol inhibited the liver cancer growth by 36.3%
at the lower dosage and 40.3% at the higher, it continued to grow
on placebo. Resveratrol at a dosage of 10mg/kg was added to two
different dosages of 5-FU, a commonly used chemotherapeutic drug.
The 5-FU was given at 10mg'kg or 20mg/kg. In mice receiving 5FU
10mg/kg with Resveratrol the growth of the liver tumor was inhibited
by 72.4% and with the Resveratrol plus 5-FU at the 20mg/kg dosage
the growth of the liver cancer was inhibited by 77.4%. 5-FU alone
at 10mg/kg inhibited the growth by 43.8%, and at 20mg/kg 5-FU the
growth was inhibited by 53.4%. The Resveratrol increased the
effectiveness of the chemotherapeutic drug 5-FU in liver cancer
while also decreasing its toxicity. The study is published in the
October 2004 issue of the World Journal of Gastroenterology.
Commentary by Jerry Hickey, R.Ph.
One of the mechanisms of action where cabbage vegetables protect
breast tissue and lower the risk of breast cancer is by stimulating
the creation of Quinone Reductase in the breast.