Review of how Green Tea Polyphenols, Grape Seed Extract and Milk Thistle inhibit skin cancer

May 07, 2007

Scientists at the Department of Dermatology, University of Alabama at Birmingham and their Comprehensive Cancer Center state that the suns radiation suppresses the immune system and this is a cause for the development of skin cancer. This is confirmed in studies of patients who take immune suppressing drugs to prevent rejection of a transplanted organ, and in patients with biopsy-proven skin cancers. Solar radiation suppresses the immune system in several ways; * inhibiting immune cell function,* causing the release of immune suppressing factors,* and causing DNA damage in the skin. Dietary botanicals are of particular interest in this radiation-cancer process because they have been shown to inhibit radiation induced immune suppression and the suns cancerous effects. Selected dietary products including Green Tea Polyphenols, Grape Seed Extract, and Silymarin from Milk Thistle have evidence showing that they inhibit the skin cancer process and prevent ultraviolet radiations ability to suppress the immune system;* they improve control and regulation of the skins immune system keeping it strong and effective yet minimizing inflammation,* they repair damaged DNA,* and stimulate T-cells that identify and kill tumor cells. The review is published in the March 21st issue of the journal Cancer Letters.

Review of mechanisms for Trans-Resveratrols breast cancer preventive effects

Trans-Resveratrol is a polyphenol found in some plants and fruits. It has been found to possess cancer chemopreventive effects by inhibiting diverse cellular events associated with the initiation of the cancer process, and the promotion and progression into cancer. Resveratrol is a phytoestrogen. It binds to estrogen receptor sites and affects genes in a good way. In this study, scientists added Trans-Resveratrol to two breast cancer cell lines and a fibrocystic breast cell line. The Trans-Resveratrol influenced the activity of genes that control the cell cycle, destroy damaged and mutated cells, control the adhesion of cells, and inhibit metastasis correlating with cancer preventing activities. Resveratrol is even more active a cancer chemopreventive agent in estrogen receptor positive tumor cells. The review is published in the journal Cancer and Nutrition; 56(2).