There is a great deal of debate about the use of supplements with antioxidant
activity in conjunction with chemotherapy. Some argue that antioxidants soak up
free radicals generated by ?some? chemotherapeutic drugs diminishing treatment
efficacy. Others suggest that antioxidants mitigate toxicity allowing for
uninterrupted treatment schedules and a reduced need for lowering chemotherapy
doses (lowering doses can lead to treatment failure).
The objective of this study was to systematically review the literature to
compile results from randomized trials to evaluate the concurrent use of
antioxidants with chemotherapy. The scientists found a large body of studies;
845 randomized, controlled clinical trials. They could not perform a
meta-analysis because too many different forms of cancer with too many treatment
protocols were covered by the studies. To further filter the studies, the
researchers decided to include only those that focused on both tumor response as
well as a statistical analysis comparing post-treatment survival rates. 19
clinical trials included both of these important parameters (few studies are
designed to include both of these outcomes). The antioxidants evaluated were
Glutathione, Melatonin, Vitamin A, Antioxidant combinations, Vitamin C, NAC,
Vitamin E, and Ellagic Acid. The patients in most of these studies had advanced
cancers or cancer recurrence; often worst case scenarios.
The scientists conclude that none of the trails reported evidence of clinically
significant decreases in treatment efficacy due to the addition of antioxidant
supplementation during chemotherapy. Many of the studies indicated that
antioxidant supplementation resulted in either increased survival times,
increased ability to shrink the tumor, or both. The patients on antioxidants had
fewer cases of toxicity than chemo-only patients. The study review is published
in the March 14th, 2007 issue of Cancer Treatment Reviews. The collaborative
work was performed by scientists from the University of Illinois at Chicago (the
Program for Collaborative Research in the Pharmaceutical Sciences), and from the
Institute for Integrative Cancer Research and Education in Evanston, Illinois.
Grape Seed Polyphenols may lower the incidence of sun related skin cancers
In this study, researchers from the University of Alabama, Birmingham, exposed
hairless mice to ultraviolet radiation (just like sunlight); these mice have
little or no ability to protect themselves from ultraviolet radiation and are
commonly used in skin research. They were split into two groups; one group
received a standard diet while the second group received the standard diet with
the addition of Grape Seed Proanthocyanidins; commonly known as OPCs. In the
mice receiving Grape Seed Extract supplying OPCs there were 65 fewer cancerous
tumors and if they did occur they were up to 78% smaller. The study was just
presented at the 233 Annual Meeting of the American Chemical Society in Chicago.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to treat, diagnose, cure, or prevent any disease.
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