Resveratrol with Red Wine Polyphenols improve blood vessel function and blood flow in patients with coronary heart disease
In patients with coronary heart disease the endothelial lining of blood vessels doesn't function
properly and cannot adjust to differences in blood flow. This deleteriously affects heart rate and
blood pressure. In healthy blood vessels the endothelial lining reacts to larger volumes of blood
flow and the vessels can open (dilate); this helps lower blood pressure and decreases stress on the
In this study, 30 male patients with coronary heart disease were given either a Red Grape Polyphenol
Extract or placebo and then had their blood vessel function checked (before supplementation or
placebo) and again 30, 60 and 120 minutes after receiving the Red Grape Polyphenols or placebo.
The Red Grape Polyphenols mimicked those in Red Wine and included a variety of Red Wine Polyphenols
and Trans-Resveratrol. The Red Grape Polyphenol Extract caused the blood vessels to open to support
improved blood flow. This improvement was significantly greater then before supplementation with
almost a 50% greater dilation of blood vessels. The placebo had no effect on dilating blood vessels.
The study is published in the December 2005 issue of the European Journal of Cardiovascular
Prevention and Rehabilitation; the official journal of the European Society of Cardiology.
Commentary by Jerry Hickey, R.Ph.
At the start of this study the impact of the supplements Green Tea Extract and CLA were not
even thought of yet - studies show these both impact weight.
Mayo Clinic doctors find that patients with low grade B-cell leukemia are responding to Green Tea Extracts high in EGCG
Researchers from the Division of Hematology at the Mayo Clinic in Rochester, Mn. Have recently
published a paper where especially the Green Tea polyphenol EGCG caused leukemia B-cells from a
majority of patients with chronic lymphocytic leukemia (CLL) to die in laboratory studies. After
publishing the paper, they had 4 patients with low grade B-cell leukemia enter their medical clinic
and they found the patients had started Green Tea Extracts high in EGCG on their own. Before
starting the EGCG the patients had clinical evidence of worsening leukemia. Soon after starting
the extract high in EGCG it was found that in 3 out of 4 of these patients there was clinical
evidence that the Green Tea Extract was killing the leukemia cells and their condition was improving.
The Mayo Clinic has recently started a Phase I/II study on decaffeinated Green Tea Extract high in
EGCG for the treatment of CLL (funded by the NIH). The report is published in the November 30th, 2005
issue of the journal Leukemia Research.