TNF-alpha (tumor necrosis factor-alpha) is an important chemical secreted by the immune system. Unfortunately, it also causes drastic inflammation and damage when released inappropriately. As it turns out, TNF-alpha also triggers bone loss, and plays a critical role in bone loss after menopause.
These scientists have previously shown that Grape Seed Proanthocyanidins inhibit the ability of the sun's ultraviolet B radiation to cause cancerous changes on the skin of mice. Ultaviolet B radiation also causes localized suppression of the immune system of damaged skin, and this is part of the skin cancer process. In this study local swelling of the ear, an inflammatory reaction caused by ultraviolet B radiation exposure, was significantly lower in mice who were fed a Grape Seed Proanthocyanidin supplemented diet vs.
Preadipocytes eventually mature into full blown adipocytes (fat cells). In this study EGCG inhibited the maturing of preadipocytes to fat cells by inhibiting an enzyme in the fat cell called Cdk2. Inhibiting this enzyme prevents the cell from progressing into a mature adipocyte that can swell by absorbing fat (this in turn makes you wider and heavier) and also inhibits the formation of additional fat cells.
A glioma is a brain tumor formed by glial cells. Glial cells are cells that surround and normally provide energy, nutrients, and other forms of support for the nerve cells in the brain. Glioma cells characteristically infiltrate surrounding brain tissue diffusely.
In this randomized, double-blind, placebo-controlled clinical trial, 106 patients with early stage, age-related macular degeneration were placed on either a placebo or a combination of fish oil omega-3 fatty acids, Acetyl-L-Carnitine and Coenzyme Q10 for one year. In the supplemented group, only 1 out of 48 cases (2%) went on to develop clinically significant worsening of the visual field, whereas 9 out of 53 patients on placebo (17%) developed significant worsening. There was significantly less drusen covered area in the supplemented group (drusen are tiny yellow or white deposits in the retina).
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