Ubiquinol improves infertility in men

January 08, 2013

 Doctors from the Department of Urology, at Northwestern University’s Feinberg School of Medicine investigated the effects of Ubiquinol, the reduced form of Coenzyme Q10 on infertile 228 men in a randomized, double-blind, placebo-controlled trial. The effect of Ubiquinol on semen quality was analyzed.

The study's population was composed of 228 men with at least 2 yr of idiopathic infertility diagnosed by at least two semen analyses confirming oligoasthenoteratozoospermia (semen with a reduced amount of sperm present and the sperm may be damaged). The men were randomized into two groups and underwent 26 weeks of treatment, during which the subjects in the experimental group received a once-daily oral dose of 200 mg Ubiquinol following a meal, whereas those in the control group received a similar regimen of placebo. The treatment period was followed by a 12-wk treatment-free phase. Throughout the duration of the study, the investigators measured semen parameters, serum hormone levels, and seminal plasma antioxidant activity to assess treatment efficacy.

Following the 26-wk treatment period, the investigators found statistically significant increases in sperm density, motility, and morphology in the experimental group compared to controls. Hormonal analysis demonstrated a significant decrease in serum follicle-stimulating hormone levels with an accompanying increase in inhibin B, as well as a decrease in luteinizing hormone and a (nonsignificant) increase in testosterone, in the experimental group. Seminal plasma antioxidant levels measured via Catalase–like and Superoxide Dismutase–like activity were also significantly increased in the Ubiquinol group versus placebo group following treatment.    

Discontinuation of Ubiquinol with the treatment-free period saw seminal parameters regress toward baseline values, although significant differences in sperm density and motility were maintained; the sperm retained healthiness although its quantity decreased after the discontinuation of Ubiquinol. Finally, the longer the supplementation with Ubiquinol the healthier the sperm in regard to sperm density, motility, and morphology (health).Based on these findings, the authors concluded that Ubiquinol administration results in significant seminal parameter improvements in infertile men with idiopathic oligoasthenoteratozoospermia. The study is published in the journal European Urology, December 2012.