Perna canaliculus (Green Lipped Muscle) may aid inflammatory bowel disease

October 10, 2005

An extract of green-lipped muscle (Perna canaliculus) is used for arthritis. Mice were given Perna canaliculus extract or a placebo daily for 13 days (also vs. other oil supplements). On the seventh day of supplementation they were treated with a chemical that causes digestive tract inflammation for the balance of the 6 days to mimic inflammatory bowel disease such as colitis. The Perna canaliculus significantly reduced the loss of colon cells, reduced body weight loss (usually due to poor digestion related to inflammation) and reduced the disease activity index. The study is published in the April 2005 issue of the Journal of Gastroenterology.

Commentary by Jerry Hickey, R.Ph.

Do not just depend on medication to lower your cholesterol, focus on diet and nutrition and include plant sterol containing foods or plant sterol containing supplements as part of your daily healthy lifestyle.

Green Tea Extract protects the liver from Tamoxifen

Tamoxifen is used to treat existing advanced breast cancer, to decrease the risk of recurrence of breast cancer or to decrease the risk of developing an initial bout of breast cancer in high risk women. However, one of the drawbacks with tamoxifen is that it can be toxic to the liver (other serious effects are increased risk of blood clots, increased risk of uterine sarcoma cancer, increased risk of endometrial cancer, worsening of endometriosis, with less serious effects such as weight gain and hot flushes). In fact it actually has some ability to cause liver cancer.

Female rats were given a high dose of tamoxifen for 7 successive days to cause liver injury. Green Tea Extract was given for 4 days before and for 14 days after the tamoxifen. The tamoxifen caused a significant drop in available liver protecting antioxidants including glutathione, superoxide dismutase, and catalase. Tamoxifen increased oxidizing free radical levels in the liver and increased liver enzyme levels (SGOT and SGPT) indicating actual liver damage. Giving the Green Tea Extract to a group of the rats with tamoxifen toxicity significantly improved the liver antioxidant levels, significantly curbed the level of liver inflaming free radicals and significantly lowered liver enzyme levels. The study is published in the September 30th, 2005 issue of the Journal of Biochemistry and Molecular Biology.