Patients with treatment resistant depression and chronic fatigue syndrome lack CoQ10

August 17, 2010

  There is now evidence that major depression is accompanied by inflammatory and oxidative stress and oxidation of nitrogen compounds and by lowered antioxidant activity. Researchers from Maes Clinics in Antwerp measured plasma Coenzyme Q10 levels in 35 depressed patients and 22 normal volunteers. Treatment resistance, severity of illness and the presence of chronic fatigue were also compared.

     The researchers found that plasma CoQ10 was significantly lower in depressed patients than in the healthy and 51.4% of the depressed had plasma CoQ10 levels lower than the lowest levels detected in non-depressed individuals. Plasma CoQ10 was significantly lower in treatment resistant depression patients and in chronic fatigue syndrome patients compared to the other depressed patients.

     Patients with depression are at risk of death from heart failure and research shows that low CoQ10 increases the risk for heart failure; according to the researchers this is one reason why depressed patients are at risk for death from heart failure; low CoQ10 levels.  The study is published in the journal Neuroendocrinology Letters; 2009;30(4).