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Lab animals (rats) were exposed to a large dose of x-ray radiation. However, a group of these animals were supplemented with Grape Seed Extract for four weeks before the toxic exposure. Blood samples were taken 24 hours after irradiation. The animals given Grape Seed Extract had higher levels of antioxidants and a lower level of free radical induced peroxidation of fats showing a protective ability of Grape Seed Extract with x0-ray radiation. The study is published on line ahead of print in the July 11th 2007 issue of the journal Phytotherapy Research
High doses of DIM with Sulforaphane strongly block the growth of colon cancer in this cellular study.
Isothiocyanates of which Sulforaphane is the most important, and indoles of which DIM is among the most active metabolite (DIM is made from I-3-C and I-3-C is found in the vegetables), both come from cabbage vegetables. Both inhibit the growth of cancer cell lines and cause their destruction. They both act differently and in this study scientists from the German Cancer Research Center in Heidelberg want to see if because of differing mechanisms of anticancer activity will they be stronger when used together. They studied the combination at differing concentrations in human colon cancer cell lines. When both were combined at food level doses they cancelled each other out. But when combined at higher doses they had an additive effect strongly blocking the cycle where one cancer cell divides into two cancer cells (G2/M). Neither compound alone caused this blockage effect. The study is published in the July 2007 issue of the journal Carcinogenesis.