Mice were bred to have life-long low levels of manganese-SOD,
with 50% less SOD activity in all tissues throughout life. These mice had elevated oxidative damage. The DNA in their chromosomes,
referred to as nuclear-DNA had increased damage versus normal mice.
The levels of nuclear-DNA damage increased with age and at 26
months was significantly higher than normal mice, with a 15%
increased damage to nuclear-DNA in the heart and greater than 60%
damage to the nuclear-DNA in the liver. Mitochondrial-DNA was also
more damaged in tissues including the liver and brain. This
increased oxidative damage to the DNA is associated with a 100%
risk of developing cancer). The study appears in the December 2003
issue of the journal Physiological Genomics.
Commentary by Jerry Hickey, R.Ph.
The DNA within the chromosome in the nucleus of the cell is more
effectively protected than the DNA in the mitochondria of the cell.
Lacking Superoxide Dismutase decreased the ability to protect this
genetic material. If an important part of the DNA within the
chromosome is damaged, such as a tumor suppressing gene, the DNA
can encode copies of this mutated version of itself allowing the
formation of a cancerous tumor. When you supplement with an orally
absorbable form of Superoxide Dismutase it couples with three
different minerals, manganese, copper, and zinc. Depending on the
tissue, the appropriate combination of SOD and its mineral protect
this tissue. The combination that protects the DNA is the manganese
Resveratrol and Propolis Fight Late Stage Prostate Cancer
The nutrients Resveratrol and Propolis were tested on
androgen-resistant prostate cancer; this resembles the last
stage of prostate cancer. Both nutrients caused the cancer
cells to die from multiple causes. The study is published in
a recent issue of the journal Oncology Research
The Role of Chempreventive Agents in Cancer Therapy
The formation of a cancerous tumor is a multi-step process
triggered by carcinogens (cancer causing substances, e.g. tobacco,
radiation, pollutants). Extensive research in the last few years
has revealed that regular consumption of certain fruits and
vegetables can decrease the risk of acquiring specific cancers.
Phytochemicals derived from these fruits and vegetables are
referred to as chemopreventive agents (nutrients that decrease
the risk of cancer). They include Genestein (from soybeans),
Resveratrol (from red wine), Diallyl sulfide and S-Allyl Cysteine
(from garlic especially when aged), Allicin (from fresh garlic),
Lycopene (from tomato oleoresin), Capsaicin (from cayenne peppers),
Curcumin (Turmeric), 6-Gingerol (from ginger), Ellagic Acid (from
berries and pomegranate), Ursolic Acid (from loquat), Silymarin
(from milk thistle), Anethol (from anise and fennel), Catechins
(from green tea, apple skins, red wine, and garlic), and Eugenol
These agents have been shown to suppress the proliferation of
cancer cells (proliferation is the increase in number of cancer
cells due to uncontrolled growth and cell division). They inhibit
the effects of growth factors, inhibiting the growth and maturing
of cancer cells. They induce the otherwise immortal cancer cells
into committing cellular suicide. They short circuit the cancer
process by inhibiting cancer associated enzymes and proteins. They
inhibit the ability of cancer cells to create their own blood
supply and routes of nourishment. They inhibit cancer causing
cellular inflammatory mediators. They may have untapped therapeutic
These chemopreventive agents also very recently have been found to
reverse the ability of cancerous tumors to shield themselves from
the effects of chemotherapy and radiation in patients undergoing
cancer treatment. Thus these chemopreventive agents have potential
to be used as adjuncts to current cancer therapies. The report as
formulated at the Comprehensive Cancer Center, Our Lady of Mercy
Medical Center, New York Medical College, Bronx, New York. The study
is published in the November 25th issue of Cancer Letters.
Commentary by Jerry Hickey, R.Ph.
You can add to this list the following:
Isothiocyanates in cabbage vegetables (Sulforphane)
Glucosinolates in cabbage vegetables (D-Glucarate)
Indoles in cabbage vegetables (Indole-3-Carbinol)
The study appears in the November 25th, 2004 issue of Cancer Letters.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to treat, diagnose, cure, or prevent any disease.
All customer information is kept confidential. We do not give, rent or sell our customer information. Customer information is kept for company records only.