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L-Carnosine Extends Lifespan and Protects Chromosomal Telomeres

Oct 13, 2004

At the end of your Chromosome is a strand of thousands of copies of repetitive genes known as telomeres. They serve a very important function, extending the lifespan of a cell. To create a new cell, the cell must go through a process known as morphogenesis. In this process one cell splits into two new healthy cells. So to heal a wound or replace old worn out cells morphogenesis must occur. During the process the DNA unravels and creates two identical new "you" cells. A portion of the gene, the telomere portion, is cut off in the process so the real DNA that is needed to encode for a new healthy cell remains intact. When you use up enough of the telomere strands the cell can no longer divide and dies. Without telomere strands at the end of the chromosome, cells could not be replaced and you probably wouldn't have made it to your first birthday.

L-Carnosine, the potent anti-glycation, antioxidant, has the ability to delay cellular senescence (aging) and has the ability to extend the lifespan of old cells rejuvenating and protecting them. As it turns out L-Carnosine protects telomeres, reduces their shortening and extends their life. This is an important reason why L-Carnosine rejuvenates old cells and why it has life extending ability. The study is published in the November 2004 issue of the journal Biochemical and Biophysical Research Communications.

GliSODin Helps Prevent Worsening Disease in Many Dangerous Chronic Illnesses

Endothelial cells are a single layer of flat cells that line blood vessels and the heart (they also line the lymphatic system and other organs). Bleeding occurs when these cells are torn or ruptured until a clot forms. The generation of free radicals from these endothelial cells causes when damaged causes accumulating damage in many cardiovascular disorders.

Endothelial cells if damaged, release free radicals including: superoxide, hydrogen peroxide, peroxynitrite, and hydroxyl free radicals. The superoxide free radical is highly unstable and is responsible to a degree for generating the other free radicals including the bleaching hydrogen peroxide, and the very dangerous peroxynitrite free radical. These free radicals have a number of negative effects on the heart and blood vessels including:

  1. Rapid inability to relax blood vessel walls (relaxing blood vessel walls allows easier blood flow)
  2. Progressive free radical tissue destruction
  3. Redox signaling where free radicals trigger or worsen disease.

High levels of blood fats, a lack of oxygen, poor blood flow, inflammation, and other stressful conditions are some of the triggers for the formation of the superoxide free radical from endothelial cells.

In other words, damage to endothelial cells leads to free radical production. The free radicals, especially the superoxide free radical lead to vascular and heart damage. This progression is an important physiological component of the worsening of many dangerous-chronic diseases including diabetes, atherosclerosis, heart failure, stroke, and post heart attack damage. The study is published in the November 2004 issue of the American Journal of Physiology - Regulatory, Integrative and Comparative Physiology.

Commentary by Jerry Hickey, R.Ph.

The production of free radicals in blood vessel walls leads to massive tissue damage and is an important part of the disease process that leads to morbidity and eventually mortality. Chief among these free radicals is the superoxide free radical. Superoxide Dismutase (or SOD) is the antidote to this dangerous and highly inflammatory free radical. The only orally absorbable form of SOD on the market is GliSODin. GliSODin increases levels of our body's SOD. If SOD is accompanied by Catalase, you also have the antidote to hydrogen peroxide. Giving this combination will reduce free radical damage seen in diabetes, cardiovascular disease and many other serious conditions.