L-Carnosine Extends Lifespan and Protects Chromosomal Telomeres
At the end of your Chromosome is a strand of thousands of copies
of repetitive genes known as telomeres. They serve a very important
function, extending the lifespan of a cell. To create a new cell,
the cell must go through a process known as morphogenesis. In this
process one cell splits into two new healthy cells. So to heal a
wound or replace old worn out cells morphogenesis must occur. During
the process the DNA unravels and creates two identical new "you"
cells. A portion of the gene, the telomere portion, is cut off in
the process so the real DNA that is needed to encode for a new
healthy cell remains intact. When you use up enough of the telomere
strands the cell can no longer divide and dies. Without telomere
strands at the end of the chromosome, cells could not be replaced
and you probably wouldn't have made it to your first birthday.
L-Carnosine, the potent anti-glycation, antioxidant, has the
ability to delay cellular senescence (aging) and has the ability
to extend the lifespan of old cells rejuvenating and protecting
them. As it turns out L-Carnosine protects telomeres, reduces their
shortening and extends their life. This is an important reason
why L-Carnosine rejuvenates old cells and why it has life extending
ability. The study is published in the November 2004 issue of the
journal Biochemical and Biophysical Research Communications.
GliSODin Helps Prevent Worsening Disease in Many Dangerous Chronic Illnesses
Endothelial cells are a single layer of flat cells that line blood
vessels and the heart (they also line the lymphatic system and
other organs). Bleeding occurs when these cells are torn or ruptured
until a clot forms. The generation of free radicals from these
endothelial cells causes when damaged causes accumulating damage
in many cardiovascular disorders.
Endothelial cells if damaged, release free radicals including:
superoxide, hydrogen peroxide, peroxynitrite, and hydroxyl free
radicals. The superoxide free radical is highly unstable and is
responsible to a degree for generating the other free radicals
including the bleaching hydrogen peroxide, and the very dangerous
peroxynitrite free radical. These free radicals have a number of
negative effects on the heart and blood vessels including:
- Rapid inability to relax blood vessel walls (relaxing blood vessel walls allows easier blood flow)
- Progressive free radical tissue destruction
- Redox signaling where free radicals trigger or worsen disease.
High levels of blood fats, a lack of oxygen, poor blood flow,
inflammation, and other stressful conditions are some of the
triggers for the formation of the superoxide free radical from
In other words, damage to endothelial cells leads to free radical
production. The free radicals, especially the superoxide free
radical lead to vascular and heart damage. This progression is an
important physiological component of the worsening of many
dangerous-chronic diseases including diabetes, atherosclerosis,
heart failure, stroke, and post heart attack damage. The study is
published in the November 2004 issue of the American Journal of
Physiology - Regulatory, Integrative and Comparative Physiology.
Commentary by Jerry Hickey, R.Ph.
The production of free radicals in blood vessel walls leads to
massive tissue damage and is an important part of the disease
process that leads to morbidity and eventually mortality. Chief
among these free radicals is the superoxide free radical.
Superoxide Dismutase (or SOD) is the antidote to this dangerous
and highly inflammatory free radical. The only orally absorbable
form of SOD on the market is GliSODin. GliSODin increases levels
of our body's SOD. If SOD is accompanied by Catalase, you also
have the antidote to hydrogen peroxide. Giving this combination
will reduce free radical damage seen in diabetes, cardiovascular
disease and many other serious conditions.