Indole-3 Carbinol supplementation helps reduce symptoms and sore size in women with dysplasia of the vulva

Dysplasia of the vulva is often caused by the wart virus (human papilloma virus). In this study women with high grade vulvar intraepithelial neoplasia; a dysplasia of the vulva region which can progress into cancer, were treated with either Indole-3 Carbinol at 200mg a day or 400mg a day. Symptomatology and appearance were assessed at recruitment, at 6 weeks, 3 months and 6 months of supplementation at which point a biopsy was performed. There was a significant improvement in symptoms with a decrease in pain and itching. The size and severity of the lesion were also significantly reduced however the biopsy of the worst affected regions showed no improvement. The effects of 200mg and 400mg a day of Indole-3 Carbinol was somewhat similar. The study was performed at the Northern Gynecological and Oncology Center, Queen Elizabeth Hospital, UK, and is published in the March-April 2006 issue of the International Journal of Gynecological Cancer. Commentary by Jerry Hickey, R.Ph.; Indole-3 Carbinol is very helpful with stage 1 and 2 cervical dysplasia. These women had advanced vulvar dysplasia. Perhaps it is recommended to take at least some Indole-3 Carbinol preventatively at least some days per week.