A great deal of exciting information has been coming out of prestigious research
institutions concerning the possibility of extending the maximal human lifespan
and certainly the healthspan. The research is based on successfully extending
the lifespan of primates via restricting their daily calorie intake while still
ensuring good nutrition. The excitement concerns the ability of Resveratrol, and
to a lesser degree other phytochemicals, ability to mimic this activity; all of
the benefits of caloric restriction without the pain of lifelong extreme
The rational for this is that if you were starving, genes become active that
extend the lifespan of your individual cells so that you survive the famine;
otherwise after a famine there would be no survivors. The longer each of your
individual cells survive, the longer you live. It has been found that
restricting calories mimics the effects of starvation; and this works over the
long term; causing these survival genes to activate and extend cellular
lifespans. Now it has been discovered that supplementing with Resveratrol also
stimulates these genes to extend lifespan. These genes also ofset the negative
effects of excessive insulin release and high blood sugar levels and the impact
disease has on aging.
The enzymes involved in this protective. life-extending process are Sirtuins.
Improving the level of Sirtuins in animals has dramatically increased the
lifespan in a number of different species. Improving Sirtuin levels has also
attenuated the degeneration and death of brain cells in animal versions of
Huntington's disease and Alzheimer's disease. Increasing Sirtuin activity either
by caloric restriction or by supplementing with Resveratrol could be brain
protective in several ways; cleaving the protein associated with Alzheimer's
disease, and improving the rate of clearance and disposal of Alzheimer's
protein. Brain cell inflammation would be reduced and the death of or damage to
brain cells would be reduced. The improved Sirtuin activity also stimulates
genes that shield brain cells from damage and shock, and block the death of
brain cells. Sirtuin activity greatly slows brain-neuronal degeneration and
neuronal degeneration is a major aspect of human aging. The study is published
in the February 16th, 2007 issue of the journal Molecular Aspects of Medicine.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to treat, diagnose, cure, or prevent any disease.
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