High Dosage Folic Acid supplementation reduces the risk of estrogen positive breast cancer/ Multiple-Vitamins decrease the risk associated with alcohol consumption

Researchers at the Fred Hutchinson Cancer Research Center in Seattle, and at the University of Washington, Seattle, examined any connection between high Folic Acid supplementation and breast cancer risk. They also examined any connection with methionine, riboflavin, and vitamins B-6 and B-12 from self-reported intakes averaged over 10 years before the start of the study.
35,023 postmenopausal women aged 50 to 76 years in the Vitamins And Lifestyle (VITAL) cohort study took part in the analysis. Breast cancer was diagnosed in 743 of these women between baseline (2000–2002) and 2006. Cox proportional hazards models  Women consuming from 1272 dietary folate equivalents of total folate (10-year average intake) had a 22% decrease in breast cancer risk compared with women consuming less than 345 DFE/d. A greater preventive benefit was observed for estrogen-receptor (ER) negative than for ER+ breast cancers decreasing the risk of estrogen positive breast cancers vs. estrogen negative breast cancers by 62%. The other supplements offered no protection and were not related to breast cancer.
Drinking alcohol is a known risk factor for breast cancer and taking a Multivitamins decreased this increased risk of breast cancer associated with alcohol drinking.
The study is published online ahead of print in the June 20, 2008 issue of the American Journal of Clinical Nutrition.