Green Tea Polyphenols (GTP) were added to chemotherapy-drug
resistant cancer cells. Adding the GTP increased the ability
of the cancer chemotherapeutic agent doxorubicin to fight the
cancer by 5.2 times. The GTP increased the concentration of
doxorubicin in the cancer cells and decreased the ability of the
tumor cells to push out the chemotherapy. The study is published
in the October 2004 issue of the Journal of Pharmacy and
Commentary by Jerry Hickey, R.Ph.
A major cause of drug resistance to chemotherapy is the ability
of cancer cells to push the drugs out of the cell before they have
a chance to take effect. Green tea polyphenols have the ability
to help reverse this disastrous activity. Recent studies have
shown that the amino acid L-Theanine, and the red wine constituent
Resveratrol also posess this amazing ability.
Different Polyphenols Inhibit Prostate Cancer Growth by Different Mechanisms
Turmerics constituent Curcumin is a powerful inhiitor of prostate
cancer cell growth. Whereas Green Teas major polyphenol EGCG, and
the Red wine polyphenol Resveratrol inhibited the prostate cancer
cell cycle at the S-phase. The S-phase of the cell cylce is
crucial. At this point in a cells life a flurry of activity takes
place as the cell prepares to create new cance cells. Quercetin
found in green tea, garlic, and apple skins, Genestein from Soybeans,
and Curcumin from Turmeric inhibited the prostate cancer cell
cycle at the G2M phase, a phase of the cell cycle more progressed
than S-phase. All of these polyphenols induced the death and
destruction of prostate cancer cells and they all worked differently.
The study is published in the November 2004 issue of the journal
Nutrition and Cancer/p>
Grape Seed OPCs Fight Colon Cancer
The effect of Grape Seed Proanthocyanidins (GSP) was tested on rat
precancerous colon tissue. The regeneration of abnormal precancerous
cells was greatly reduced by GSP. The actual number of precancerous
cells was significantly decreased, and the death rate for these cells
was greatly accelerated. The activity of the colonic tissues immune
system to fight the progression to colon cancer was improved. In a
second study, Grap Seed Pronathocyanidins strongly inhibited colon
cancer cells and caused them to die. The study is published in the
October issue of the journal Nutrition and Cancer.
Maitake Mushroom Polysaccharides Improve Immune Function in Cancer Patients
The polysaccharide fraction from Maitake Mushroom (MMP) has been
shown to exert its anticancer activity in tumor bearing mice by
improving immune function and immune surveillance. It acheives
this by activating immune cels (macrophages, T-cells, and Natural
Killer Cells). MMP in combination with chemotherapy enhanced the
drugs ability to shrink cancerous tumors of the lung, liver, and
breast of cancer patients. In this study, MMPwas given to cancer
patients who were not currently taking chemotherapy. The MMP
hindered cancer metastasis, decreased tumor markers (elevations
otumor markers signal worsening-progressing disease), and
increased the activity of Natural Killer Cells. Natural Killer
Cells are immune cells that patrol for, identify, and call in the
immune cells to destroy abnormal, precancerous, and cancerous
cells. The study is published in the Winter 2003 issue of the
Journal of Medicinal Foods.
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