Grape Seed Extract helps lower blood pressure
Metabolic syndrome is a cluster of risk factors that increase the risk of developing diabetes and
cardiovascular disease (hardening of the arteries) which occur together in one person. Metabolic
syndrome is usually due to overeating poor food choices, not exercising, and to a degree, genetic
factors. Having high LDL-cholesterol and triglycerides, insulin resistance, high blood pressure, a
pro-inflammatory state, and obesity are characteristic of metabolic syndrome.
Scientists from the University of California, Davis carried out a human clinical trial using various
dosages of Grape Seed or placebo on both men and women with diagnosed metabolic syndrome. They were
placed on either 150mg or 300mg of Grape Seed Extract, or placebo. At the end of one month it was
found that all of those on Grape Seed Extract had a significant drop in their elevated blood pressure
with the systolic pressure dropping 12 mm Hg on average and the diastolic pressure dropping 8 mm Hg on
average (systole/diastole). Also for the individuals on the higher potency Grape Seed extract there was
a good drop in the level of oxidized LDL-cholesterol. The study was presented at the recent American
Chemical Society Meeting in Atlanta.
Studies show it is not the caffeine which helps decrease
the risk of developing diabetes but probably the polyphenols.
More evidence that Resveratrol helps prevent kidney damage
Rhabdomyolysis is a painful destruction of muscle fibers causing the
release of muscle content into the circulation. Levels of Creatine kinase
(or CCK - an enzyme that creates energy in the muscle) and myoglobin
(the oxygen carrying protein in muscle that functions like hemoglobin)
increase in the blood. These patients generally feel muscle
tenderness and muscle aching.The urine can become dark or cola colored.
Rhabdomyolysis leads to kidney damage, kidney failure, and death.
Rhabdomyolysis accounts for 10% to 40% of all cases of sudden kidney
failure (acute renal failure). Statin drugs that reduce cholesterol have caused
rhabdomyolysis and then death in some patients.
In this study a large amount of a chemical was injected into rats to cause acute
renal failure due to rhabdomyolysis. Injury to the kidney was assessed by
measuring the level of plasma creatinine, blood urea nitrogen, and blood
creatinine (not the supplement creatine) in the plasma and by urea
clearance by the kidneys.Giving Resveratrol supplementation 60 minutes
before injecting the chemical markedly decreased damage to kidney tissue,
a drop in kidney function, and production of inflammatory free radicals,
while improving antioxidant enzyme levels in the kidneys (protective levels
of glutathione, glutathione reductase, catalase, and superoxide dismutase).
The study is published in the current issue of the journal Renal Failure