Grape Seed Extract- a Natural Chemical Found in Grapes May Protect Against Alzheimer's Disease
Researchers at Mount Sinai School of Medicine have found that Grape Seed Extract -- a natural and very powerful antioxidant -- may help prevent the development or delay the progression of Alzheimer's disease. The research team was led by Giulio Maria Pasinetti, MD, PhD, The Saunder Family Professor in Neurology, and Professor of Psychiatry and Geriatrics and Adult Development at Mount Sinai School of Medicine.
This is the first study to evaluate the ability of grape-derived polyphenols to prevent the generation of a specific form of β-amyloid (Aβ) peptide, a substance in the brain long known to cause the neurotoxicity associated with Alzheimer disease. In partnership with a team at the University of Minnesota led by Karen Hsiao Ashe, MD, PhD, Dr. Pasinetti and his collaborators administered Grape Seed Extract to mice genetically determined to develop memory deficits and Aβ neurotoxins similar to those found in Alzheimer's disease. They found that the brain content of the Aβ*56, a specific form of Aβ previously implicated in the promotion of Alzheimer's disease memory loss, was substantially reduced after treatment.
Previous studies suggest that increased consumption of grape-derived polyphenols may protect against cognitive decline in Alzheimer's. This new finding, showing a selective decrease in the neurotoxin Aβ*56 following grape-derived polyphenols treatment, corroborates those theories.
"Since naturally occurring polyphenols are also generally commercially available as nutritional supplements and have negligible adverse events even after prolonged periods of treatment, this new finding holds significant promise as a preventive method or treatment, and is being tested in translational studies in Alzheimer's disease patients," said Dr. Pasinetti.
"It will be critical to identify subjects who are at high risk of developing Alzheimer's disease, so that we can initiate treatments very early and possibly even in asymptomatic patients," said Dr. Pasinetti. "However, for Alzheimer's disease patients who have already progressed into the initial stages of the disease, early intervention with this treatment might be beneficial as well. Our study implicating that these neurotoxins such as Aβ*56 in the brain are targeted by grape-derived polyphenols holds significant promise."
This research was funded by a grant from the National Institutes of Health. The study is published online in the current issue of the Journal of Alzheimer's Disease.