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Researchers from the University of Pittsburgh randomly assigned more than 3,000 adults older than 75 to take either 120 milligrams of ginkgo or inactive placebo pills twice a day. They found that over the next six years, the Ginkgo group had a lower risk of developing peripheral artery disease (PAD), a buildup of artery-clogging plaques in the legs that reduces blood flow and can lead to pain and cramps when a person walks. The finding is in line with past research showing that ginkgo supplements helped people with PAD walk farther without pain. "Peripheral artery disease is a major public health problem and the preventive therapies are not very good," according to lead researcher Dr. Kuller. The study is published online ahead of print November 24, 2009, in the journal Circulation: Cardiovascular Quality and Outcomes.