Diabetics who break down L-Carnosine too quickly develop kidney failure

January 31, 2008

Diabetes is the leading cause of end-stage renal disease worldwide. This requires either a kidney transplant or kidney dialysis treatments for survival. A research team from Wake Forest University School of Medicine and the University of Heidelberg has found that diabetics that have a particular type of gene involved with the protective factor Carnosine do not develop kidney failure.
L-Carnosine is a protective factor shown to be active in the heart, liver, kidneys, brain, eyes, skin and likely other tissues. The Carnosinase 1 gene on human chromosome 18 is responsible for creating Carnosinase; the enzyme that degrades the protective factor L-Carnosine. In comparing this gene in858 subjects including diabetics with end-stage kidney failure (294 patients), diabetics without kidney damage (258 patients) and healthy non-diabetics (306 people) it was found that those who break down L-Carnosine inappropriately tend to develop kidney disease. L-Carnosine appears to prevent scarring from developing in the kidneys and serves as a scavenger of kidney damaging free radicals. The study is published in the January 5th, 2007 issue of the journal Nephrology, Dialysis, Transplantation.

Carnosine may protect the lungs from scarring

Pulmonary fibrosis is a dangerous even fatal condition characterized by a build up of scar tissue in the lungs; this makes it difficult to breath and function. The condition puts pressure on the heart to supply more oxygen, eventually enlarging the heart, leading to heart failure. These patients are treated with drugs and oxygen and their treatment is often dangerous and must be managed by a lung specialist known as a pulmonologist.
Many drugs can cause pulmonary fibrosis, so can a number of autoimmune diseases (and so can their medical treatment), exposure to dusts from coal, asbestos, even bird feeders can also cause the condition. Pneumonia and other lung conditions also can cause it.
In this study a drug (the antibiotic bleomycin), was introduced into the lungs of mice which lead to scarring. A group of the mice were supplemented daily with L-Carnosine. A week later the mice were checked. The mice receiving L-Carnosine (by mouth just like we would take it) had a reduced loss of body weight (a common symptom of severe disease that contributes to dying), a lower mortality rate, less swelling of the lungs that would have been due to a build up of fluids in them (pulmonary edema), less lung inflammation, less lung injury and importantly, less fibrosis. The study is published in the January 12, 2007 issue of the American Journal of Physiology.

Nutrients in Broccoli May Help Protect the Heart, according to the results of an animal study

Here's another reason to eat broccoli: It may help your heart.
University of Connecticut researchers report that news after studying broccoli and heart health in rats.
The scientists brewed a broccoli-extract and fed it to rats for a month in addition to regular rat chow. For comparison, they fed other rats water instead of the broccoli extract in addition to their regular chow.
After feeding the rats either broccoli-extract or water for 30 days, the scientists tested the rats' hearts. Some of those tests deprived the heart of oxygen, similar to a heart attack.
The rats that had eaten the broccoli extract had three heart advantages over the other rats:
- Better blood-pumping ability (the opposite of heart failure)
- Less heart damage during oxygen deprivation (the heart attack caused less damage)
- Higher levels of heart-health chemicals during oxygen deprivation (this would help protect the heart and reduce damage to it)
Broccoli's key nutrients include selenium and Sulforaphane, both of which may also curb cancer, notes D. Das, PhD.
Their findings appear in the Journal of Agricultural and Food Chemistry.