Due to the site upgrade, your MY ACCOUNT logins will need to be updated. Please access Forgot Your Password to make this change. If you do not have an account, click here.

Diabetics who break down L-Carnosine too quickly develop kidney failure

Jan 16, 2007

Diabetes is the leading cause of end-stage renal disease worldwide. This requires either a kidney transplant or kidney dialysis treatments for survival. A research team from Wake Forest University School of Medicine and the University of Heidelberg has found that diabetics that have a particular type of gene involved with the protective factor Carnosine do not develop kidney failure.

L-Carnosine is a protective factor shown to be active in the heart, liver, kidneys, brain, eyes, skin and likely other tissues. The Carnosinase 1 gene on human chromosome 18 is responsible for creating Carnosinase; the enzyme that degrades the protective factor L-Carnosine. In comparing this gene in858 subjects including diabetics with end-stage kidney failure (294 patients), diabetics without kidney damage (258 patients) and healthy non-diabetics (306 people) it was found that those who break down L-Carnosine inappropriately tend to develop kidney disease. L-Carnosine appears to prevent scarring from developing in the kidneys and serves as a scavenger of kidney damaging free radicals. The study is published in the January 5th, 2007 issue of the journal Nephrology, Dialysis, Transplantation.