According to a report in the April 10th, 2003 issue of the New England Journal
of Medicine, one-third of patients with epilepsy have drug resistant epilepsy.
Because this form is resistant to multiple antiepileptic drugs making it difficult
to treat it is associated with an increased risk of death and debilitating psychosocial
consequences. Studies show it is a genetic factor that leads to this drug-therapy
resistance. Doctors at the Department of Pediatrics and Pediatric Neurology
at Mashhad University of Medical Sciences state that in traditional medicine,
Nigella Sativa (Black Seed) has been known for its anticonvulsant effects. This
plant is naturally distributed in the Middle-East and has been widely used as
a natural remedy for a long time.
In this double-blinded crossover clinical trial conducted on children with refractory
epilepsy, a liquid extract of Black Seed was administered as an adjunct to medical
therapy and the effects were compared with those of a placebo. Twenty children
completed the study (13 months to 13 years old, 10 boys and 10 girls). All patients
were receiving constant treatment for at least one month before the study. They
received extract (40 mg/kg/8 h) or placebo for a period of four weeks and in
the cross-over between these periods for two weeks they received only their
pre-existing anti-epileptic drugs. RESULTS: The mean frequency of seizures decreased
significantly during treatment with extract Black Seed Extract in both groups.
The study is published in the December 2007 issue of Medical Science Monitor;
International Medical Journal of Experimental and Clinical Research.
Effect of citrus flavonoids and tocotrienols on serum cholesterol levels
in hypercholesterolemic subjects
Preliminary studies show that Citrus Flavonoids and Palm Tocotrienols both independently
reduce cholesterol levels in laboratory animals. In the following three human
clinical trials a combination of Citrus Flavonoids and Tocotrienols were used
to gauge its ability to lower cholesterol. All participants were hypercholesterolemic
men and women with cholesterol levels greater than 230 mg/dL and all were between
the ages of 19 and 65 years when recruited.
In the first study (open-label) 10 patients were given a combination of 270mg
Citrus Flavonoids and 30mg Tocotrienols or they were given inactive placebo
daily for four-weeks. In the second study (also open-label) 10 patients were
given the same combination once again for four-weeks. In the third study which
was double-blinded, 120 patients were given the same combination of 270mg Citrus
Flavonoids and 30mg Tocotrienols or they were given inactive placebo, but this
time for twelve-weeks. Measurements of fasting levels of blood cholesterol,
low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides
were made at baseline and 4 weeks (all groups) and at 8 weeks and 12 weeks.
Significant reductions were shown in total cholesterol with a drop of 20%-30%,
LDL with a drop of 19%-27%, apolipoprotein B dropped 21%, and triglycerides
dropped 24%-34% in all groups. HDL levels remained unchanged in the four-week
trials but increased by 4% in the twelve-week trial and this was accompanied
by a significant increase in apolipoprotein A1 by 5%; this is the active lipoprotein
found in HDL. The study is published in the November-December 2007 issue of
the journal Alternative Therapies in Health and Medicine.
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