Benefits derived from combining EPA-DHA (from cold water-fatty fish) with Phosphatidylserine
EPA and DHA are omega-3 fatty acids derived from ocean-going cold-water fish
such as salmon. They are conditionally essential nutrients that enhance quality
of life and lower the risk of premature death. These fats function exclusively
on our cells membrane where they are anchored by phospholipids such as Phosphatidylserine.
The cell membrane is the outside layer of the cell that regulates communication
between cells and controls what is permitted to enter or exit our cells.
DHA is essential for prenatal and postnatal brain development, whereas EPA seems more influential on behavior and mood. Both DHA and EPA generate metabolites that protect brain and nerve tissue. In double-blind, randomized, controlled trials, combinations of EPA with DHA benefit ADHD, autism, dyspraxia (a condition where the brain cannot control coordination), dyslexia, and aggression.
For the affective disorders (they affect mood), and meta-analysis of multiple studies confirm benefits in major depressive disorder, bipolar disorder, with promising results for schizophrenia and initial benefit for borderline personality disorder.
Low levels of EPA and DHA in tissue correlate with accelerated cognitive decline and mild cognitive impairment and supplementation has improved cognitive function. Huntington disease has responded to supplementation with EPA.
Combining EPA and DHA with Phosphatidylserine into the same molecule have shown marked promise in early clinical trials. The combination has alleviated ADHD symptoms. Utilizing EPA and DHA along with Phospholipids along with membrane antioxidants achieves a triple cell membrane synergy that may further diversify the currently wide range of applications of fish oil EPA-DHA. The study is published in the September 2007 issue of the journal Alternative Medicine Review.