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5 Essential Micronutrients During Pregnancy By: Jun Wang, MS


July 2015

5 Essential Micronutrients During Pregnancy
By: Jun Wang, MS.

In about three months, I will became a father for the first time in my life. My wife and I are very excited, yet nervous for the day to come. Maintaining a healthy and nutritious diet is the top priority on the seemingly never ending list most pregnant women have. With a plethora of dietary advice, such as taking more protein, and consuming more fish, calcium, folate, milk and so on, it can be difficult to determine what nutrients are the most important. Thankfully, as a nutritionist, I have conducted my own research and have concluded that there are five essential micronutrients that are required during pregnancy.

Folate is a water-soluble B vitamin, naturally found in foods such as leafy dark-green vegetables, yeast, legumes, asparagus, fruits, nuts, orange juice, and beef liver. Folic acid is the synthetic form of folate, usually found in fortified foods and nutritional supplements. [1] Two major biochemical functions of folate are methionine synthesis and DNA synthesis. The former requires folate as a coenzymes to convert homocysteine to methionine.[1] The latter requires folate in the synthesis of thymidylate and purines, both of which are needed for DNA synthesis.[1] Insufficient intake of folate during preconception and first trimester is associated with higher risk of Neural Tube Defects, including anencephaly and spina bifida (incomplete closure of the neural tube over the brain or spine), since closure normally completes by 28 days after fertilization when pregnancy is not yet recognized. [2] Also, autism spectrum disorder was reduced 38% in women with an intake of 600 ug of folic acid daily.[3] Recommended Dietary Allowances of folate during pregnancy is 600 mcg DFE(Dietary Folate Equivalent)*/day.[1]

Vitamin B12
Vitamin B12 is also a water-soluble B vitamin, naturally found in animal tissues like meat, seafood, poultry, dairy products and eggs. It is required in synthesis of succinyl Co-A, which is needed for metabolism of branched amino acids in proteins (valine, isoleucine and threonine), metabolism of fats and synthesis of hemoglobin. [1] Also, it is a co-factor with folate to convert homocysteine to methionine. Vitamin B12 deficiency during pregnancy can cause infant growth retardation, hypotonia, megaloblastic anemia and reduced brain growth.[4] Recommended Dietary Allowances of vitamin B12 during pregnancy is 2.6 mcg/day.[1]

Iron is a mineral required for red blood cell metabolism, oxygen supply and normal cellular functioning.[1] World Health Organization identifies iron deficiency as the number one nutritional disorder in the world. 24.8% of the world's population have iron deficiency anemia. [5] Dietary iron has two main forms: heme and nonheme. Heme iron includes lean beef, oysters, clams, turkey and fish. Non-heme iron includes spinach, fortified cereals, instant oatmeal, beans, lentils and soybeans. Pregnant women are among the high need for iron group, because oxygen demand is doubled during pregnancy. Iron deficiency causes pregnant women anemia, which can raise risk for undergrown or preterm babies [6]; reduced hemoglobin, iron and ferritin in cord blood resulting in newborn anemia; delayed infant mental function [7]. Recommended Dietary Allowances of iron during pregnancy is 27 mg/day. [1] Upper limit of iron intake for pregnancy is 45 mg/day, since excessive iron can cause liver damage, dizziness and constipation. [8]

Iodine is a trace element, naturally found in seaweed, dairy products, grain products, egg and iodized salt. It is mainly needed for thyroid hormone synthesis, which increases 50% during pregnancy. [9] Thyroid hormones control metabolic activity, regulate protein synthesis and promote enzyme activity. [1] Iodine deficiency during pregnancy can affect development of skeleton and central nerve system in fetus and child. Also fetus depends on maternal thyroxine supply in early pregnancy before thyroid develops and lack of iodine can result in cretinism, which can cause mental retardation. [9] Recommended Dietary Allowances of iodine during pregnancy is 220 mcg/day. [1] Upper limit of iodine intake is 1100 mcg/day for pregnancy, because excessive iodine can cause goiter and hypothyroidism by inhibiting hormone synthesis. [10]

Vitamin D
Vitamin D is a fat-soluble vitamin, mainly obtained from sun exposure and found in foods such as mushroom, tuna, salmon, sardine, herring, mackerel and fortified foods. It is recently recognized as one of the most important micronutrients in the body, which involves calcium homeostasis, bone formation and growth, cell proliferation and differentiation, immune function, gene expression, hormone secretion and brain growth.[1] Vitamin D deficiency during pregnancy can cause rickets and failure of mineralization of teeth and bones in newborn and osteomalacia in mother.[11] Also, lower maternal serum vitamin D is correlated with both maternal insulin resistance and lower APGAR(Appearance Pulse Grimace Activity Respiration) scores of newborns.[12] Recommended Dietary Allowances of vitamin D during pregnancy is 600 IU/day. Upper limit of vitamin D intake is 4,000 IU/day. However, several studies conclude that daily intake of 4,000 IU is necessary and safe for pregnant women to achieve healthy level of Vitamin D and prevent complications of its deficiency.[13][14]

Consuming natural food is the optimal choice to receive all of these nutrients. However, a high quality of dietary supplements can be complementary to guarantee the sufficient daily intake of these five essential micronutrients during pregnancy.

1. Folate: http://ods.od.nih.gov/factsheets/Folate-HealthProfessional/#en1
2. MMWR Recomm Rep. 1992 Sep 11;41(RR-14):1-7. Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects.
3. Schmidt RJ. Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study. Am J Clin Nutr doi: 10.3945/ajcn.110.004416.
4. Medicine (Baltimore). 2015 Mar;94(9):e584. doi: 10.1097/MD.0000000000000584. Growth retardation, general hypotonia, and loss of acquired neuromotor skills in the infants of mothers with cobalamin deficiency and the possible role of succinyl-CoA and glycine in the pathogenesis. Bicakci Z1.
5. Iron: http://apps.who.int/iris/bitstream/10665/84408/1/9789241505529_eng.pdf
6. Br J Nutr. 2015 May 6:1-8. Maternal iron status in early pregnancy and birth outcomes: insights from the Baby's Vascular health and Iron in Pregnancy study. Alwan NA1, Cade JE2, McArdle HJ3, Greenwood DC4, Hayes HE3, Simpson NA5.
7. Pediatrics. 2013 Mar;131(3):e755-63. doi: 10.1542/peds.2011-3513. Epub 2013 Feb 11. Effect of iron deficiency anemia in pregnancy on child mental development in rural China.
8. Iron Deficiency: http://www.nlm.nih.gov/medlineplus/ency/article/002659.htm
9. Nutrients. 2011 Feb;3(2):265-73. doi: 10.3390/nu3020265. Epub 2011 Feb 18. Iodine deficiency in pregnancy: the effect on neurodevelopment in the child. Skeaff SA1.
10. Thyroid. 2001 May;11(5):501-10. Iodine-Induced hypothyroidism. Markou K1, Georgopoulos N, Kyriazopoulou V, Vagenakis AG. 11. Clin Nutr. 2014 Dec 17. pii: S0261-5614(14)00304-5. doi: 10.1016/j.clnu.2014.12.006. [Epub ahead of print] Congenital rickets due to vitamin D deficiency in the mothers. Paterson CR1, Ayoub D2.
12. Afr Health Sci. 2015 Jun; 15(2): 523–531. doi: 10.4314/ahs.v15i2.27 PMCID: PMC4480463 Relation of maternal vitamin D status with gestational diabetes mellitus and perinatal outcome Niyazoglu Mutlu,1 Hatipoglu Esra,1 Aydogan Begum,2 Dellal Fatma,3 Yavuz Arzu,4 Hacioglu Yalcin,5 Kaya Fatih,5 and Kumru Selahattin6
13. J Bone Miner Res. 2011 Oct;26(10):2341-57. doi: 10.1002/jbmr.463. Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. Hollis BW1, Johnson D, Hulsey TC, Ebeling M, Wagner CL.
14. J Clin Endocrinol Metab. 2013 Jun;98(6):2337-46. doi: 10.1210/jc.2013-1154. Epub 2013 Apr 4. Randomized Controlled Trial (RCT) of Vitamin D Supplementation in Pregnancy in A Population with Endemic Vitamin D Deficiency. Dawodu A1, Saadi HF, Bekdache G, Javed Y, Altaye M, Hollis BW.

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