Alzheimer's Could be Diabetes-like Illness, Study Suggests
It is a recent discovery that the brain produces insulin. Now, a new study reveals that as
Alzheimer's disease progresses, insulin production in the brain decreases.
"Many of the unexplained features of Alzheimer's, such as cell death and tangles in the brain,
appear to be linked to abnormalities in insulin signaling. This demonstrates that the disease
is most likely a neuroendocrine disorder, or another type of diabetes," said senior researcher
Suzanne M. de la Monte, a neuropathologist at Rhode Island Hospital and a professor of pathology
at Brown University medical School.
The Brown University team discovered that brain levels of insulin and its correlated cellular
receptors fall dramatically in the early stages of Alzheimer's. They revealed that the loss of
insulin and insulin-like growth factor in the brain is directly associated with low levels of
acetylcholine, which is a significant characteristic of Alzheimer's. The report appears in the
November issue of the Journal of Alzheimer's Disease.
Commentary by Jerry Hickey, R.Ph.
At the start of this study the impact of the supplements Green Tea Extract and CLA were not
even thought of yet - studies show these both impact weight.
Blueberry, Aronia Berry, and Blackcurrant liquid extracts rich in Anthocyanins may help protect the cardiovascular system
Endothelial cells are the cells that line the entire cardiovascular system from the heart to even
the smallest blood vessels (capillaries). Prostaglandin E2 (PGE2) is needed for many physiological
functions; it is a hormone like substance but unfortunately it tends to be pro-inflammatory. PGE2
contributes to inflammation in the circulatory system and blood vessel damage. In human endothelial
cells exposed to oxidizing agents it was found that extracts from anthocyanin rich berries inhibited
this function. Blueberry liquid extract, Aronia berry liquid extract, and Blackcurrant liquid extract
all if rich in Anthocyanins, inhibited the release of PGE2 in endothelial cells and were antioxidants
and anti-inflammatory. The study is published in the September 2005 issue of the Journal of