ALCAR + ALA restore function to blood vessels and lower blood pressure in patients with cardiovascular disease
Damage to the power plants of your cells (known as mitochondria) results in
dysfunction of organs and systems throughout your body and it is an important
aspect of the slowdown and disease process that occurs with aging. A great deal
of the damage that occurs to these power plants is caused by accruing damage
caused by oxidative free radicals (antioxidants are the antidote to free radical
damage). Two well known and extensively studied nutrients are known to help
restore energy production to the cellular power plants as well as defend them
from free radicals; Acetyl-L-Carnitine (commonly referred to as ALCAR) and Alpha-Lipoic
Acid (referred to as ALA).
Researchers from Boston University School of Medicine gave 36 patients with
cardiovascular disease ALCAR + ALA or they gave them inactive placebo for 8
weeks. They were then crossed-over to the other treatment for an additional
8 weeks; those who took the nutrients now took placebo and vice versa for those
who originally took placebo. The ALCAR + ALA worked both as antioxidants and
also as rejuvenators for the mitochondrial power plants restoring their function.
Those heart patients with high blood pressure or those who also had metabolic
syndrome had a 9 point drop in systolic blood pressure on average. The supplements
restored function to the arteries in all patients improving the dilation by
2.3%. This means that the arteries were able to do the job of opening more widely
and not restricting blood flow; this is what medication for treating high blood
pressure tries to achieve but in different ways, typically by blocking activities
in the peripheral nervous system or that part of the nervous system outside
of the brain and spinal column (this also explains the many side effects of
the drugs). The study is published in the April 2007 issue of the Journal
of Clinical Hypertension.
ALCAR or ALA for restoring mental function and nerve health
Damage to the power plant of our cells known as mitochondria results in decay
and a decreased ability to supply energy resulting in diminished function in
all things throughout our body. This is an important contributor to the loss
of mobility, generalized slowing down, the decrease in power of the senses,
and especially the pathologies that occur as we age.
Researchers at the Nutritional Genomics Center, Children’s Hospital Oakland
Research Institute in California state that this leads to a loss of mobility
and brain function in laboratory animals and in humans. Giving ALCAR with ALA
to lab animals restores better mobility and brain function.
A recent meta-analysis looking backwards from 2004 found 21 human clinical trials
showing that ALCAR is useful for restoring cognitive function in the elderly
with the typical-mild cognitive impairment seen in just about everyone and even
improved brain function in those with milder stages of Alzheimer’s disease
demonstrating significant efficacy vs. placebo. A meta-analysis of 3 clinical
trials shows that ALA improves neuropathy in diabetes vs. placebo (please note;
there have been many additional studies since 2004 on both substances used independently
or in conjunction). The review appears in the November 2004 edition of the Annuals
of the New York Academy of Sciences.