Add GliSODin to your list of select supplements before major or invasive surgery

February 06, 2007

In invasive surgery, a surgery which is complex and requires penetration into internal areas of the body, blood flow is interrupted and then reintroduced to the involved tissues. This generates a large volume of cell destroying free radicals that lead to tissue damage. This damage is called ischemia-reperfusion injury; to put this in perspective similar damage occurs after a stroke or heart attack due to the reintroduction of blood. The spinal cord and the kidneys are the most vulnerable organs to this form of damage. If the organs and tissues can be protected from the free radicals they will suffer less damage.

In this study one group of swine were supplemented with GliSODin for two weeks and the second group received placebo (swine have similar antioxidant profiles to humans). Then a major invasive procedure was performed. GliSODin significantly reduced the damage caused by the reintroduction of blood flow; DNA damage was decreased in cells. And spinal cord cell death was decreased. Additionally, venous acidosis was decreased; a condition where the blood becomes acidic, this acidosis is harmful to heart function. Organ function was not impaired with GliSODin supplementation. The study is published on line ahead of print in the journal Intensive Care Medicine, January 20th, 2007.

Evidence that GliSODin protects the kidneys in diabetes

Diabetes often causes kidney damage and can lead to kidney failure and the need for dialysis to remove waste products from the blood. Free radical damage to kidney cells is implicated in the progression of disease. GliSODin (oxykine in Japan) is the cantaloupe melon derived SOD covered by chains from wheat protein (polymeric films of wheat matrix gliadin). SOD is a powerful anti-inflammatory/antioxidant that is well absorbed by humans (SOD is normally destroyed in the digestive tract).

In this study researchers at the Molecular Gastroenterology and Hepatology Department in the Graduate School of Medical Science in Kyoto, Japan treated rodents with diabetes with GliSODin; an important time to supplement because kidney damage already starts in pre-diabetes; they are catching it early on before gross damage occurs. Giving GliSODin over a 12 week period significantly inhibited the leakage of protein into the animals? urine vs. non-supplemented animals. The kidney cells of the supplemented animals were also significantly healthier. Diabetic animals not supplemented with GliSODin also had more inflammation in their kidneys. The study is published in the journal Biofactors, 2005;23(2).