Adiponectin is a very-very good hormone released by fat cells. Adiponectin
actually burns fat, protects the liver, and improves insulin sensitivity and
improved insulin sensitivity is the opposite of diabetes. The very strange
paradox is that as people gain weight their fat cells release less adiponectin.
Low adiponectin is related to fatty liver disease, obesity, heart disease and
diabetes. Research has shown that Resveratrol improves adiponectin levels in
A number of
studies also show that Resveratrol improves insulin sensitivity in people with
pre-diabetes. This is related to Resveratrol being an exercise mimetic reducing
the amount of fat in muscle and increasing muscle leanness, glycogen storage and
In this new study
obese but still healthy men were supplemented with either inactive placebo or
with 150mg of Resveratrol daily for 30 days. Then they went through a one-month
washout period where no placebo or Resveratrol was used; this washes out the
effects of the previous supplementation. At that point they were crossed-over to
the other group and the men previously receiving placebo now took Resveratrol
for 30 days and vice-versa in the second group.
resulted in a shrinking in the size of fat cells in both legs of the study and
the men lost capacity to fill small-immature fat cells with fat – the core of
obesity; it was preventing re-plumping of the men’s belly fat. In fact the
Resveratrol was actually decreasing the number of fat cells and this is
very-very important. Unless an overweight person goes through a prolonged period
of rigorous exercise and calorie cutting they don’t actually decrease the number
of belly fat cells and this eventually defeats their diet. In other words when
an obese person diets the billions of additional fat cells on their belly shrink
in size but they are still present. Once depleted these now thinner fat cells,
known as adipocytes, release the hunger hormone known as ghrelin. Ghrelin makes
you fell starved and you eat excessively again and gain your weight back. With
Resveratrol not only do the fat cells shrink back to a normal or more normal
size but they decrease in number; therefore less ghrelin is released, there is
less stimulation of the appetite and less of the yo-yo dieting effect. Shrinking
of adipocytes is one way Resveratrol may also be improving insulin sensitivity.
The study is published online in the International Journal of Obesity.
Commentary on Resveratrol dosage by Jerry
Hickey, R.Ph.: In successful studies using Resveratrol it seems to work well
in total daily dosages of 75mg to 200mg. Higher dosages used in some studies
lead to decreasing levels of Resveratrol’s benefits including reducing it’s fat
burning potential so more is not better apparently. In studies where Resveratrol
improved blood sugar or decreased inflammation in the heart the potencies used
were generally 75mg to 150mg of active Trans-Resveratrol.
Discussing systemic versus localized
effects of Resveratrol by Jerry Hickey, R.Ph.: This is very interesting -
Resveratrol research again and again demonstrates that it’s effects locally are
different than its effects systemically; locally meaning a specific region of
the body and systemically meaning much of or the entire body. For instance
Resveratrol stimulates specific immune system activity that triggers the process
of inflammation in fat cells; the body uses this to remove fat cells. However
systemically in the heart and arteries, the brain, lungs, liver, pancreas,
muscles and kidneys Resveratrol lowers inflammation. Another example of a
fortunate paradox is Resveratrol’s impact on new blood vessel growth. You want
new blood vessel growth in the heart so that in the case of a heart attack the
heart continues to receive at least some blood and oxygen improving the odds of
survival. It is just the opposite with cancer. Cancerous tumors have poor blood
supplies so they trigger the release of enzymes and hormones that create new but
fairly inefficient and weak blood vessels; in this way cancer can grow and
spread. Resveratrol improves blood vessel formation in the heart (collateral
circulation) but inhibits the process in cancerous tumors (by inhibiting VEGF
and MMP enzymes produced in tumors; VEGF creates blood vessels in tumors and MMP
enzymes break down the barrier into healthy tissue allowing growth and spread).
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to treat, diagnose, cure, or prevent any disease.
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